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Genome Plasmid

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Summary

Machine-generated summary

The University of Edinburgh awarded a contract for a genome plasmid. The plasmid is to be produced to FDA, IND ready standard for use in manufacturing a lentiviral vector for a clinical trial treating a rare genetic disease that causes progressive dementia in children. The therapy uses autologous haematopoietic stem progenitor cells modified ex vivo with a lentiviral vector to express a secreted enzyme in myeloid progeny, delivering enzyme to the central nervous system. The plasmid will be delivered directly from the supplier to the University of California Los Angeles, the University of Edinburgh's partner in the project. Indiana University won the contract, awarded on 2025-08-14.

Description

We are planning a clinical trial to treat a rare genetic disease that causes progressive dementia in children. Our therapy is based on the following: Autologous haematopoietic stem progenitor cells (HSPCs) are modified ex vivo with a lentiviral vector (LV) to express supraphysiologic levels of a secreted enzyme in myeloid progeny, in essence using gene-modified monocytes/macrophages as a durable and effective vehicle for central nervous system (CNS) enzyme delivery. In order to progress this therapy, we require the following; a plasmid to our specification, produced to FDA, IND ready standard for use in the manufacture of a lentiviral vector for clinical trial. This Plasmid will be delivered directly from the supplier to the University of Edinburgh’s partner in the project, University of California Los Angeles. (SC Ref:828196)

Official source

Source: Public Contracts Scotland

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Last verified against Public Contracts Scotland 1 day ago

Documents on Public Contracts Scotland (English)

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