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TED - Tenders Electronic Daily (Publications Office of the EU) verified 3 days ago Contract notice

Germany - Research and development services and related consultancy - Framework contract for research services on the development and synthesis of Liver X Receptor ligands

Original Deutschland - Forschungs- und Entwicklungsdienste und zugehörige Beratung - Rahmenvertrag über einen Forschungsdienstleistungsauftrag zur Entwicklung und Synthese von Liganden des Liver X Rezeptors

Closed Germany Research & development

Buyer Universitätsklinikum Bonn AöR

Key facts

Closed
10:00 (UTC+2)
Procedure
Open procedure
  1. Published
  2. Deadline open for 14 days
  3. Awarded pending
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Summary

Machine-generated summary

The buyer seeks a framework contract for research services to develop, synthesise and supply novel, highly affine and well-tolerated ligands of the Liver X Receptor (LXR). The structures must be new and not previously described in publicly accessible sources, produced in sufficient quantities for further analyses and first applications in cell and small animal models, using green chemistry principles. The aim is a potential new drug class against degenerative aortic valve stenosis, which currently has no medication and affects over one million people in Germany. Place of performance: Germany.

Description

Die degenerative Aortenklappenstenose (AS) ist die häufigste tödliche Herzklappenerkrankung in den Industrieländern und betrifft allein in Deutschland über 1 Millionen Frauen und Männer mit einer 5-JahresSterblichkeitsrate von bis zu 80%. Weltweit gibt es bislang kein einziges Medikament für die Behandlung oder die Prävention der AS. Die einzige Therapie, die aktuell verfügbar ist, ist der Ersatz der erkrankten Klappe durch eine Prothese. Dies ist nicht nur für die Patienten belastend, sondern auch mit hohen Kosten verbunden. Aktuell belaufen sich diese auf über 2 Milliarden Euro jährlich, allein in Deutschland. In der Vergangenheit wurden einige Versuche unternommen, Medikamente für die Behandlung oder die Prävention der AS zu entwickeln. All diese Versuche sind bis heute erfolglos. Durch unsere grundlegende Arbeit im DFG-geförderten Sonderforschungsbereich "Aortenerkrankungen" (TRR 259) konnten wir zeigen, dass verschiedene Mechanismen, die zur Entstehung der AS führen, gehemmt werden können durch die Aktivierung des Rezeptors "Liver X Receptor" (LXR). ALLSTARS entwickelt gut verträgliche, selektive und hochpotente Liganden des LXR. Dies könnte der entscheidende Durchbruch für die Entwicklung einer neuen Medikamentenklasse zur pharmakologischen Behandlung der degenerativen AS sein. Ziel des Auftrags ist die Entwicklung, Synthese und Bereitstellung hoch affiner und gut verträglicher Liganden des LXR. Die Strukturen müssen neuartig sein, d.h. sie dürfen nicht in einer öffentlich zugänglichen Quelle vorbeschrieben sein. Die neuen Liganden müssen in ausreichender Menge produziert werden, um weiterführende Analysen, sowie erste Anwendungen in Zell- und Kleintiermodellen zu ermöglichen. Alle Synthesen sollen nach den Prinzipien der grünen Chemie erfolgen.

Terms of the procedure

How tenders are scored
Angebotspreis für das maximale Kosten-Volumen wird mit 30 % gewichtet: 30 percent; Zuschlagskriterium Qualität: 70 percent
Small firms
The buyer does not mark this procedure as suitable for small and medium-sized firms.

As the official notice states them.

Official source

Source: TED - Tenders Electronic Daily (Publications Office of the EU)

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Last verified against TED - Tenders Electronic Daily (Publications Office of the EU) 3 days ago

Universitätsklinikum Bonn AöR

Germany

notices in the register
206
awards
53
awarded in total
€18.7M

Who wins its contracts

Many suppliers
different companies won its awards
36
of the awards went to the three most frequent winners
15%
of its calls state an estimated value
17%

Based on 40 awards with a named winner over the last 3 years. Counted by award, not by value, because lot and framework amounts are not comparable. Concentrated means the three most frequent winners took 65% or more of the awards; many suppliers, under 35% with at least ten different winners.

Competition

tenders per lot on average (open and restricted procedures)
5.3
of those lots received a single tender
8%
of the awards went to companies based in another country
0%

As the official award notices state them, over the last 3 years. Tenders per lot count open and restricted procedures only: in a negotiated procedure or a direct award a single tender is the procedure itself. The country is the one the notice gives for the winner.

One dot per award, on the day it was signed, sized by its value. A ring is an award with no published value.

Awards most often to

  1. Münch GmbH 2 awards €399,452
  2. Datennetzbau Theurich 2 awards €231,622
  3. SVA System Vertrieb Alexander GmbH 2 awards

10 open tenders right now

Market context

open now in Research & development
432
median open notice
€300,000

Who wins in this market

Many suppliers

Germany · Research & development

different companies won awards here
361
of the awards went to the three most frequent winners
6%
buyers awarded contracts here
126

Based on 456 awards with a named winner over the last 3 years. Counted by award, not by value, because lot and framework amounts are not comparable. Concentrated means the three most frequent winners took 65% or more of the awards; many suppliers, under 35% with at least ten different winners.

Competition

tenders per lot on average (open and restricted procedures)
2.8
of those lots received a single tender
40%
of the awards went to companies based in another country
16%
of the tenders came from another country
35%

As the official award notices state them, over the last 3 years. Tenders per lot count open and restricted procedures only: in a negotiated procedure or a direct award a single tender is the procedure itself. The country is the one the notice gives for the winner.

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