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Microscale thermophoresis device

Original Finland - Laboratory, optical and precision equipments (excl. glasses) - Microscale thermophoresis device

Open Contract notice 16 days left
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Deadline 9 Oct. If it moves, an email when the register sees it. A correction: the same email. Your plan: decide by 25 Sep, questions by 25 Sep, draft by 2 Oct. Log in

  1. Published
  2. Today
  3. Deadline open for 44 days
  4. Awarded pending

Summary

Machine-generated summary

University of Oulu, Biocenter Oulu, in Finland seeks a spectral shift and microscale thermophoresis device to characterise and quantify nanoparticle, including protein, interactions in solution without immobilisation. The device must detect weak to tight binders, distinguish binding events from aggregation, measure dissociation constants in the nM to mM range, use low sample volumes (around 10 microlitres), operate with fluorescence detection and temperature gradients, and be easy to use and maintain. It will join the Proteomics and protein analysis core facility with an open access policy. No estimated value, deadline or procedure details are stated in the available description, so bidders should consult the full tender documents.

Description

University of Oulu, Biocenter Oulu, seeks a spectral shift and microscale thermophoresis device to characterise qualitatively and determine quantitatively nanoparticle, including protein, interactions in the range of weak to tight binders in solution without immobilization (hereinafter referred to as the "device"). The device must enable the assessment of sample quality and aggregation and differentiating binding events from aggregation. The device will be used for analysis of interactions of fluorescence labelled proteins with small molecules and vesicles. The detection must be independent of the mass ratio of the binding partners. The device must enable fast screening of interactions as well as sensitive affinity measurement. The measurable dynamic range of dissociation constant must be at least in nM -mM range and binding affinity in at least nM -mM range. Low sample consumption (in order of 10 microlitre) and low nanomole of the labeled target is needed for the measurement. The device must enable detection of the interaction based on changes of emission spectrum of exited fluorophore under isothermal conditions and must be able to create a microscopic non-isothermal temperature field (temperature gradient) and determine nanoparticle including protein binding events based on the temperature related intensity change and fluorescence intensity change following thermophoresis under the thermal gradient. Intensity changes and/or spectrum shifts of the fluorescence probe versus ligand concentrations are measured and plotted to calculate the dissociation constant. The device must come with detailed documentation of all features. The device will be part of the Proteomics and protein analysis core facility infrastructure of Biocenter Oulu. The core facility has an open access policy, and the instrumentation and software must be easy to use and maintain. The device must include a user interface to control the operation. The device must be well suited to an academic multi-user environment. The contracting entity has a maximum sum of 189000 € (excluding value-added tax) available for the procurement and cannot accept tenders exceeding this amount. The procurement is partially funded by the European Regional Development Funds (ERDF), BioParts project (A81573).

Official source

Source: TED - Tenders Electronic Daily (Publications Office of the EU)

Always verify details on the official notice.

Last verified against TED - Tenders Electronic Daily (Publications Office of the EU) 2 weeks ago

View the official notice

More from this buyer

Full buyer profile

3 open tenders right now

Who usually wins this buyer's contracts in this sector

Company Wins Total awarded Last win
REFEYN GmbH 1 €257,559 Dec 2025
IXRF, Inc. 1 €257,242 Dec 2025
PREVAC sp. z o.o. 1 €213,490 Dec 2025

Based on 3 awards with a linked company profile over the last 5 years.

What this buyer has paid before

Based on 3 comparable contracts this buyer awarded in this sector over the last 4 years.

€235,366
Lower quartile
€257,242
Median award
€257,400
Upper quartile

Most recent awards

Award values as published by the official sources. Use them as a guide, not a rule: scope, lots and duration differ between contracts.

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Market context

Avg. open tender · Laboratory & precision equipment
€5,502,828
2,004 open across Europe right now
Buyer track record on Aperlena
32 notices tracked · 17 awarded
€7,487,390 in awarded contracts

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