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Italy - Research and development services and related consultancy services - Novel strategy for allergenicity risk assessment of proteins in regulated food and feed products

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Summary

Machine-generated summary

The European Food Safety Authority (EFSA) in Italy is procuring research and consultancy services to develop a novel strategy for allergenicity risk assessment of proteins in regulated food and feed products. The project will include open-source in silico prediction tools for cross-reactivity and de novo sensitisation, a curated allergen database, verification with experimental data, assessment of future prospects, estimation of thresholds of allergological concern, and a tiered decision-making framework. This is an open call for a single framework contract with, indicatively, four specific contracts. No estimated value or submission deadline is stated in the notice.

Description

Allergenicity risk assessment (RA) is a relevant cross-cutting issue for most EFSA Scientific Panels. As current strategies for allergenicity RA of proteins in regulated food and feed products are primarily informed by 2003 Codex Alimentarius guidelines, it is of utmost importance to take into account recent scientific advances in allergenicity RA. An open call (single framework contract with, indicatively, four specific contracts) will be launched to support EFSA in the development of a novel strategy for fit-for-purpose allergenicity RA of proteins in food and feed, building on state-of-the-art knowledge, accumulated experience, and ongoing interactions with the European Commission. This project foresees: 1) the development of an open-source in silico prediction/appraisal tool for clinically-relevant cross-reactivity, supported by a curated allergen database ranked according to clinical relevance, and by integrated phylogenetics analysis, sequence homology and structural similarity; 2) the development of an open-source in silico prediction/appraisal tool for de novo sensitisation based on the protein binding capacity to antigen-presenting cells and other aspects informing on potential sensitisation capacity; 3) the verification of the tools with experimental in vitro and in vivo data; 4) the assessment of future prospects for in silico tools to account for the impact of factors such as protein digestibility, food matrix, or processing on protein properties and allergenic potential; 5) the estimation of thresholds of allergological concern; and 6) the development of a systematic tiered/stepwise approach including a decision-making framework with defined criteria or scenarios that trigger each of the tiers. This novel strategy will enhance the reliability and speed of allergenicity RA, support process simplification and harmonisation, and ultimately enable better-informed decision-making.

Official source

Source: TED - Tenders Electronic Daily (Publications Office of the EU)

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Last verified against TED - Tenders Electronic Daily (Publications Office of the EU) 1 month ago

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Who usually wins this buyer's contracts in this sector

Company Wins Total awarded Last win
ECORYS EUROPE EEIG - GEIE; INNOVAMOL SRL; STICHTING WAGENINGEN RESEARCH 1 €474,475 Nov 2025
KPMG; ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLA LOMBARDIA E DELL'EMILIA ROMAGNA BRUNO UBERTINI 1 n/a Aug 2026
Open Analytics 1 n/a May 2026
REPLY; DELAWARE CONSULTING 1 n/a May 2026
Sovon Vogelonderzoek Nederland 1 n/a Mar 2026

Based on 7 awards with a linked company profile over the last 5 years.

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    • Estimated value: Set to €1,300,000
    • Estimated value: Set to €1,300,000

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Market context

Avg. open tender · Research & development
€3,272,461
534 open across Europe right now 60% below sector average
Buyer track record on Aperlena
63 notices tracked · 22 awarded
€1,122,475 in awarded contracts

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