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Aperlena

Italy - Research and development services and related consultancy services - Evaluation of microbiome-relevant biomarkers and in vitro models for xenobiotic risk assessment

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Summary

Machine-generated summary

EFSA in Italy is procuring research and consultancy services to evaluate microbiome-relevant biomarkers and in vitro models for assessing the effects of dietary xenobiotics on the gut microbiome and host health. The project will appraise available evidence, assess promising biomarkers and models, prioritise biomarker-model pairings, and identify suitable analytical methods. The contract notice does not state the estimated value or the submission deadline, and bid eligibility and the procedure type are not specified in the provided information. Interested suppliers should consult the full notice for these details.

Description

Addressing a key knowledge gap identified in EFSA's Gut Microbiome Roadmap, the project aims to establish foundational methodological elements for assessing the potential adverse effects of dietary xenobiotics on the gut microbiome and host health through systematic available evidence appraisal and meta-synthesis. In particular, the project will systematically evaluate promising microbiome-relevant biomarkers related to key health endpoints (e.g. intestinal barrier integrity, inflammatory responses, microbiome metabolic capacity, immune system effects, microbiome composition and function) and the suitability of available in vitro models (e.g., SHIME, triple co-culture, MBRA, organoids). It will prioritise optimal biomarker-in vitro model pairings based on regulatory science applicability and feasibility, and identify appropriate analytical methods (including omics-based approaches) for each combination. The outcomes will provide an evidence-based prioritisation framework and feasibility assessment to inform potential follow-up experimental validation of the prioritised biomarker-in vitro model combinations and support the possible integration of microbiome data into risk assessment.

Official source

Source: TED - Tenders Electronic Daily (Publications Office of the EU)

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Last verified against TED - Tenders Electronic Daily (Publications Office of the EU) 1 month ago

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    • Estimated value: Set to €300,000
    • Estimated value: Set to €300,000

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Market context

Avg. open tender · Research & development
€3,261,910
533 open across Europe right now 91% below sector average
Buyer track record on Aperlena
63 notices tracked · 22 awarded
€1,122,475 in awarded contracts

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