Skip to content
Aperlena
Language:

Ireland - Laboratory, optical and precision equipments (excl. glasses) - RFT for the Supply, Delivery, Installation, Commissioning and Calibration of Isothermal Titration Calorimeter (ITC) for Protein Complexes for Trinity College Dublin

Awarded Contract award No deadline published
Watch this tender

Bidding is closed. An award or a correction on this notice: an email when the register sees it. Log in

  1. Awarded
  2. Published

Description

Trinity College Dublin require the supply of Isothermal Titration Calorimeter (ITC) for protein complexes for the deliverables of a Research Ireland grant. The calorimeter is required for measuring micro-calories of heat evolved or absorbed from protein-protein and protein-small molecule interactions in aqueous solution. The measurement involves multiple injections of ligand (protein, other macromolecules, small molecules) into a cell containing another protein, small molecule, or other macromolecules. The titration is performed under isothermal conditions using a reference cell containing water or related aqueous solution that is similar to the experimental cell. Changes in temperature between the two cells during injections are rapidly equilibrated using active power compensation that is calibrated for calories of heat. The properties of the isothermal titration calorimeter should include the following: (1) The tenderer SHOULD provide a new or recent state-of the-art (ex-demo) model ITC calorimeter, and if ex-demo, it should be minimally used. Volume of experimental and reference cells should be approximately 200 mico-Liters. (2) Typical concentration ranges for analyses should ideally be in the range from 1 micro-Molar to 100 micro-Molar for macromolecules (typically proteins) in the cell, and 10 micro-Molar to 1M concentrations in the injections syringe for the ligand. (3) Preferred temperature range for isothermal titrations from 4 deg Celsius to 60 deg Celsius. (4) software that can analyse data and determine the Kd (dissociation constant), enthalpy, and entropy from analyses of the titrations. (5) Software should handle simple 1:1 binding models, with the possibility to analyse more complex interactions, such as multiple binding sites, sequential interactions. The capability to analyse complex binding with rigor would be a major advantage, as many interactions are not simple 1:1. (6) minimal generation of bubbles or artefactual heat, which may arise from high concentrations of viscous protein in cell (7) Ideally - prefer system/software compatibility with .opj files generated by Origin 7 (or later) software, since we have nearly 20 years of previous data collections. This could be transferred to new control computer for continuity. (8) New computer, drivers, and accessories required to run the calorimeter software.

Official source

Source: TED - Tenders Electronic Daily (Publications Office of the EU)

Always verify details on the official notice.

Last verified against TED - Tenders Electronic Daily (Publications Office of the EU) 1 month ago

View the official notice

More from this buyer

Full buyer profile

16 open tenders right now

Recent awards

Change history

Every time an official source republished this notice with different content. We watch every source we index, including regional copies of the same notice.

  1. Read before bidding
    • Estimated value: Set to €75,700
    • Award date: Awarded on May 26, 2026
    • Estimated value: Set to €75,700

Follow this tender and we email you the moment it changes. Create account

Similar tenders

Market context

Avg. open tender · Laboratory & precision equipment
€5,431,613
2,033 open across Europe right now 99% below sector average
Buyer track record on Aperlena
967 notices tracked · 744 awarded
€61,294,793 in awarded contracts

Never miss a tender like this

11 new notices in Laboratory & precision equipment in Ireland in the last 7 days. Get an email when new ones appear. Free.

Set up my alert
Source

Keyboard shortcuts

Read a list without reaching for the mouse. The shortcuts stay quiet while you type in a field.

j
Next result
k
Previous result
Enter
Open the result
n
Next page
p
Previous page
c
Compare this result
s
Shortlist this result
/
Jump to the search box
?
Show these shortcuts
Esc
Close