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In vitro ADME assays for hepatic clearance and plasma protein binding

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  1. Published
  2. Deadline open for 47 days
  3. Awarded pending

Summary

Machine-generated summary

The European Commission, DG JRC - Joint Research Centre, procured laboratory services to implement two in vitro ADME methods for determining intrinsic hepatic clearance and plasma protein binding (PPB). The contractor was to generate high-quality experimental data for a defined set of selected chemicals following JRC-provided Standard Operating Procedures (SOPs), under controlled and harmonised laboratory conditions. A secondary objective was to evaluate SOP implementation in the tenderer's laboratory to identify critical steps and support protocol refinement. The estimated value was EUR 139,999. Bidding has closed; the deadline for bids was 2026-08-31.

Description

The present contract aims to implement two in vitro ADME methods for the determination of intrinsic hepatic clearance and plasma protein binding (PPB), and to generate high-quality experimental data for a defined set of selected chemicals in accordance with the JRC-provided Standard Operating Procedures (SOPs). The primary objective is to produce robust and reliable in vitro ADME data implementing these assays under controlled and harmonised laboratory conditions. The JRC-provided SOPs serve as the methodological foundation for the technical implementation of the assays and contain all critical procedural elements required to ensure assay integrity and data quality during data generation. A secondary objective is to evaluate the implementation of the SOPs in the tenderer's laboratory in order to identify laboratory-specific critical steps and opportunities for protocol refinement, thereby supporting the development of more robust and transferable protocols.

Official source

Source: EU Funding and Tenders Portal (SEDIA) - EU institutions

Always verify details on the official notice.

Last verified against EU Funding and Tenders Portal (SEDIA) - EU institutions 6 days ago

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€3,348,400
580 open across Europe right now 96% below sector average
Buyer track record on Aperlena
235 notices tracked · 12 awarded
€5,331,889 in awarded contracts

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